Publications
A strong foundation of peer reviewed research.
- Publications
- 38
- Journals
- 10
38 publications
2026
Molecular Psychiatry
Next-generation precision medicine for mood disorders: reproducible blood biomarkers enable objective diagnostics, subtyping, and targeted therapeutic
J. Balducci, E. Gobel, M. Schmitz, J. French, A. Germanos, SC Corey, R. Bhagar, SM Kurian, A. Shekhar, H. Le-Niculescu & AB Niculescu
2026 Aug 4 · doi: 10.1038/s41380-026-03736-8doi: 10.1038/s41380-026-03736-82025
Molecular Psychiatry
Next-generation precision medicine for pain
R. Bhagar, H. Le-Niculescu, S. C. Corey, A. S. Gettelfinger, M. Schmitz, A. Ebushi, E. Matei, C. Woods, J. Mullen, S. M. Kurian, A. Shekhar, F. A. White & AB Niculescu
2025 Aug 25 · doi: 10.1038/s41398-024-03071-ydoi: 10.1038/s41380-025-03186-82024
Translational Psychiatry
Next-generation precision medicine for suicidality prevention
R. Bhagar, S. S. Gill, H. Le-Niculescu, C. Yin, K. Roseberry, J. Mullen, M. Schmitz, E. Paul, J. Cooke, C. Tracy, Z. Tracy, A. S. Gettelfinger, D. Battles, M. Yard, G. Sandusky, A. Shekhar, S. M. Kurian, P. Bogdan & A. B. Niculescu
2024 Sep 6 · doi: 10.1038/s41398-024-03071-ydoi: 10.1038/s41398-024-03071-y2024
Molecular Psychiatry
Precision medicine for psychotic disorders: objective assessment, risk prediction, and pharmacogenomics
M. D. Hill, S. S. Gill, H. Le-Niculescu, O. MacKie, R. Bhagar, K. Roseberry, O. K. Murray, H. D. Dainton, S. K. Wolf, A. Shekhar, S. M. Kurian, A. B. Niculescu
2024 Feb 8 · doi: 10.1038/s41380-024-02433-8doi: 10.1038/s41380-024-02433-82023
Discover Mental Health
Temporal effects on death by suicide: empirical evidence and possible molecular correlates
R. Bhagar, H. Le-Niculescu, K. Roseberry , K. Kosary, C. Daly, A. Ballew, M. Yard, G. E. Sandusky, A. B. Niculescu
2023 April 3 · doi: 10.1007/s44192-023-00035-410.1007/s44192-023-00035-42023
Molecular Psychiatry
Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
K. Roseberry, H. Le-Niculescu, D. F. Levey, R. Bhagar, K. Soe, J. Rogers, S. Palkowitz, N. Pina, W. A. Anastasiadis, S. S. Gill, S. M. Kurian, A. Shekhar, and A. B. Niculescu
2023 March 7 · doi: 10.1038/s41380-023-01998-0PMID: 368789642022
Discover Mental Health
Polyphenic risk score shows robust predictive ability for long-term future suicidality
M. Cheng, K. Roseberry, Y. Choi, L. Quast, M. Gaines, G. Sandusky, J. A. Kline, P. Bogdan, A. B. Niculescu
2022 June 13 · doi: 10.1007/s44192-022-00016-zPMID: 357224702021
Neuropsychopharmacology
Precision medicine in psychiatry: biomarkers to the forefront
Alexander B. Niculescu, Helen Le-Niculescu
2021 Sept 28 · doi: 10.1038/s41386-021-01183-3PMID: 345842092021
Molecular Psychiatry
Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
Le-Niculescu H, Roseberry K, Gill SS, Levey DF, Phalen PL, Mullen J, Williams A, Bhairo S, Voegtline T, Davis H, Shekhar A, Kurian SM, Niculescu AB
2021 Apr 8 · doi: 10.1038/s41380-021-01061-w. [Epub ahead of print]PMID: 338282352019
Molecular Psychiatry
Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs
Niculescu AB, Le-Niculescu H, Roseberry K, Wang S, Hart J, Kaur A, Robertson H, Jones T, Strasburger A, Williams A, Kurian SM, Lamb B, Shekhar A, Lahiri DK, Saykin AJ
2019 Dec 2 · doi: 10.1038/s41380-019-0602-2. [Epub ahead of print]PMID: 317923642019
Molecular Psychiatry
Convergence of recent GWAS data for suicidality with previous blood biomarkers: independent reproducibility using independent methodologies in independent cohorts
Niculescu AB, Le-Niculescu H
2019 August 5 · doi: 10.1038/s41380-019-0465-6. [Epub ahead of print]PMID: 313839252019
Molecular Psychiatry
Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs
Le-Niculescu H, Roseberry K, Levey DF, Rogers J, Kosary K, Prabha S, Jones T, Judd S, McCormick MA, Wessel AR, Williams A, Phalen PL, Mamdani F, Sequeira A, Kurian SM, Niculescu AB
2019 March 12 · doi: 10.1038/s41380-019-0370-z. [Epub ahead of print]PMID: 308629372019
Molecular Psychiatry
Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs
Niculescu AB, Le-Niculescu H, Levey DF, Roseberry K, Soe KC, Rogers J, Khan F, Jones T, Judd S, McCormick MA, Wessel AR, Wiliams A, Kurian SM, White FA
2019 Feb 12 · doi: 10.1038/s41380-018-0345-5. [Epub ahead of print]PMID: 307557202018
Academic Emergency Medicine
Assessing Risk of Future Suicidality in Emergency Department Patients
Brucker KM, Duggan C Roseberry K, Le-Niculescu H, *Niculescu AB, *Kline JA
2018 Oct 30 · doi: 10.1111/acem.13562. [Epub ahead of print]PMID: 303750822017
Molecular Psychiatry
Precision medicine for suicidality: from universality to subtypes and personalization
Niculescu AB, Le-Niculescu H, Levey DF, Phalen PL, Dainton HL, Roseberry K, Niculescu EM, Niezer JO, Williams A, Graham DL, Jones TJ, Venugopal V, Ballew A, Yard M, Gelbart T, Kurian SM, Shekhar A, Schork NJ, Sandusky GE, Salomon DR
2017 Sep;22(9):1250-1273 · doi: 10.1038/mp.2017.128. Epub 2017 Aug 151 PMID: 288093982017
Neuropsychopharmacology
Dissecting Suicidality Using a Combined Genomic and Clinical Approach
Niculescu AB, Le-Niculescu H
2017 42 360 · doi:10.1038/npp.2016.228PMID: 279093312016
Molecular Psychiatry
Mood, Stress and Longevity: Convergence on ANK3
Rangaraju S, Levey DF, Nho N, Jain N, Andrews KD, Le-Niculescu H, Salomon DR, Saykin AJ, Petrascheck M, and Niculescu AB
2016 Aug;21(8):1037-49 · doi: 10.1038/mp.2016.65. Epub 2016 May 24PMID: 272171512016
Molecular Psychiatry
Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment
Levey DF, Niculescu EM, Le-Niculescu H, Dainton HD, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB
2016 Jun;21(6):768-85 · doi: 10.1038/mp.2016.31. Epub 2016 Apr 5PMID: 270466452016
Molecular Psychiatry
A brief proposal for improving clinical trials
Niculescu AB
2016 Jun;21(6):736-7 · doi: 10.1038/mp.2016.42. Epub 2016 Mar 29PMID: 270218132015
eLife
Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality
Rangaraju S, Solis GM, Thompson RC, Gomez-Amaro RL, Kurian L, Encalada SE, Niculescu AB, Salomon DR, Petrascheck M. Elife
2015 Dec 1;4 · pii: e08833. doi: 10.7554 PMID: 266236672015
Molecular Psychiatry
Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach
Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD ,Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR
2015 20: 1266–1285 · doi:10.1038/mp.2015.112; Epub August 18 PMID: 262836382015
Aging Cell
Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response
Rangaraju S, Solis GM, Andersson SI, Gomez-Amaro RL, Kardakaris R, Broaddus CD, Niculescu AB, Petrascheck M
2015 Dec;14(6):971-81 · doi: 10.1111/acel.12379. Epub 2015 Aug 8 PMID: 262558862015
Molecular Psychiatry
Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions
Niculescu AB, Levey DF, Le-Niculescu H, Niculescu E, Kurian SM, Salomon, D
2015 Mar;20(3):286-8 · doi: 10.1038/mp.2014.180. Epub 2015 Jan 13PMID: 255826182014
Translational Psychiatry
Genetic Risk Prediction and Neurobiological Understanding of Alcoholism
Levey DF., H. Le-Niculescu, J. Frank, M. Ayalew, N. Jain, B. Kirlin, R. Learman, E. Winiger, Z.A. Rodd, A. Shekhar, N. J. Schork, F, Kiefe, N. Wodarz, B. Müller-Myhsok, N. Dahmer, GESGA Consortium, M. Nöthen, R. Sherva, L. Farrer, A. H. Smith, H. Kranzler, M. Rietschel, J. Gelernter, A. B. Niculescu
2014 May 20;4:e391 · doi: 10.1038/tp.2014.29. 2014 Epub May 20PMID: 248441772014
Molecular Psychiatry
DISCovery in psychiatric genetics
Niculescu AB
2014 Feb;19(2):145 · doi: 10.1038/mp.2013.176. Epub 2013 Dec 17PMID: 243429932013
Translational Psychiatry
Convergent functional genomics of stem cell-derived cells
Niculescu AB
2013 Sep 10;3:e305 · doi: 10.1038/tp.2013.78PMID: 240225102013
Molecular Psychiatry
Discovery and validation of blood biomarkers for suicidality
Le-Niculescu H, Levey D, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB
2013 Dec;18(12):1249-64 · doi: 10.1038/mp.2013.95. Epub 2013 Aug 20PMID: 239589612013
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Convergent Functional Genomics of Psychiatric Disorders
Niculescu AB
2013 Oct;162B(7):587-94 · doi: 10.1002/ajmg.b.32163. 2013 Epub May 31.2012
Molecular Psychiatry
Convergent Functional Genomics of Schizophrenia: From Comprehensive Understanding to Genetic Risk Prediction
Ayalew M, Le-Niculescu H, Levey D, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon DR, Schork NJ, Fanous A, O’Donovan M, Niculescu AB
2012 Sep;17(9):887-905 · doi: 10.1038/mp.2012.37. Epub 2012 May 152011
Translational Psychiatry
Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms
Le-Niculescu H, Balaraman Y, Patel SD, Ayalew M , Gupta J, Kuczenski R, Shekhar A, Schork N, Geyer MA and Niculescu AB
2011. Epub 2011 May 24.2011
Translational Psychiatry
Convergent Functional Genomic Studies of Omega-3 Fatty Acids in Stress Reactivity, Bipolar Disorder and Alcoholism
Le-Niculescu H, Case NJ, Hulvershorn L, Patel SD , Bowker D, Gupta J, Bell R, Edenberg HJ , Tsuang MT, Kuczenski R, Geyer MA, Rodd Z, Niculescu AB
2011. Epub 2011 April 26.2011
Molecular Psychiatry
Identification of blood biomarkers for psychosis using convergent functional genomics
Kurian SM, Le-Niculescu H, Patel SD, Bertram D, Davis J, Dike C, Yehyawi N, Lysaker P, Dustin J, Caligiuri M, Lohr J, Lahiri DK, Nurnberger Jr JI, Faraone SV, Geyer MA, Tsuang MT, Schork NJ, Salomon DR and Niculescu AB
2011 February · 16, 37–58. Epub 2009 Nov 24.2010
American Journal of Medical Genetics Part B (Neuropsychiatric Genetics)
Coming to Grips With Complex Disorders: Genetic Risk Prediction in Bipolar Disorder Using Panels of Genes Identified Through Convergent Functional Genomics
Patel SD, Le-Niculescu H, Koller DL, Green SD, Lahiri DK, McMahon F, Nurnberger JI, Niculescu AB
2010. Jun 5 · 153B(4):850-77. Epub April 9.PMID: 204680692010
American Journal of Medical Genetics Part B (Neuropsychiatric Genetics)
The P-Value Illusion: How to Improve (Psychiatric) Genetic Studies.
Niculescu AB, Le-Niculescu H
2010. Jun 5 · 153B(4):847-92010
Psychopharm Review
Toward Early, Personalized, Rational Polypharmacy In Psychiatry: A Tri-Dimensional Approach
Niculescu AB, Hulvershorn L
2010 · 45(2): 9-162010
Neuropsychopharmacology
Convergent Functional Genomics: What We Have Learned and Can Learn About Genes, Pathways, and Mechanisms
Niculescu AB, Le-Niculescu H
2010 Jan · 35(1):355-62009
American Journal of Medical Genetics Part B (Neuropsychiatric Genetics)
Convergent Functional Genomics of Genome-Wide Association Data for Bipolar Disorder: Comprehensive Identification of Candidate Genes, Pathways and Mechanisms
Le-Niculescu H, Patel SD, Bhat M, Kuczenski R, Faraone SV, Tsuang MT, McMahon FJ, Schork NJ, Nurnberger Jr JI, and Niculescu AB
2009 Mar 5 · 150B(2):155-1812009
Molecular Psychiatry
Identifying Blood Biomarkers For Mood Disorders Using Convergent Functional Genomics
Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ, Tsuang MT, Salomon DR, Nurnberger Jr JI, Niculescu AB
2009 Feb · 14(2):156-74. Epub 2008 Feb 26.